Cargando…

Cholesterol-Lowering Gene Therapy Prevents Heart Failure with Preserved Ejection Fraction in Obese Type 2 Diabetic Mice

Hypercholesterolemia may be causally related to heart failure with preserved ejection fraction (HFpEF). We aimed to establish a HFpEF model associated with hypercholesterolemia and type 2 diabetes mellitus by feeding a high-sucrose/high-fat (HSHF) diet to C57BL/6J low-density lipoprotein receptor (L...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aboumsallem, Joseph Pierre, Muthuramu, Ilayaraja, Mishra, Mudit, De Geest, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539537/ https://www.ncbi.nlm.nih.gov/pubmed/31064116 http://dx.doi.org/10.3390/ijms20092222

Ejemplares similares

Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice
por: Mishra, Mudit, et al.
Publicado: (2018)

Cholesterol lowering attenuates pressure overload-induced heart failure in mice with mild hypercholesterolemia
por: Muthuramu, Ilayaraja, et al.
Publicado: (2019)

Effective Treatment of Diabetic Cardiomyopathy and Heart Failure with Reconstituted HDL (Milano) in Mice
por: Aboumsallem, Joseph Pierre, et al.
Publicado: (2019)

HDL dysfunction, function, and heart failure
por: Mishra, Mudit, et al.
Publicado: (2019)

Increased Remnant Lipoproteins in Apo E Deficient Mice Induce Coronary Atherosclerosis following Transverse Aortic Constriction and Aggravate the Development of Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure
por: Muthuramu, Ilayaraja, et al.
Publicado: (2022)

Selective HDL-Raising Human Apo A-I Gene Therapy Counteracts Cardiac Hypertrophy, Reduces Myocardial Fibrosis, and Improves Cardiac Function in Mice with Chronic Pressure Overload
por: Amin, Ruhul, et al.
Publicado: (2017)

Administration of apo A-I (Milano) nanoparticles reverses pathological remodelling, cardiac dysfunction, and heart failure in a murine model of HFpEF associated with hypertension
por: Mishra, Mudit, et al.
Publicado: (2020)

Sarcopenic Obesity in Heart Failure With Preserved Ejection Fraction
por: Kirkman, Danielle L., et al.
Publicado: (2020)

Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis
por: Muthuramu, Ilayaraja, et al.
Publicado: (2017)

Heart failure with preserved ejection fraction
por: Rigolli, Marzia, et al.
Publicado: (2013)

Heart failure with preserved ejection fraction
por: ElGuindy, Ahmed, et al.
Publicado: (2012)

Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction
por: Samson, Rohan, et al.
Publicado: (2016)

Targeting Obesity and Diabetes to Treat Heart Failure with Preserved Ejection Fraction
por: Altara, Raffaele, et al.
Publicado: (2017)

Diabetes Mellitus and Heart Failure With Preserved Ejection Fraction: Role of Obesity
por: Dhore-patil, Aneesh, et al.
Publicado: (2022)

Obesity, Preserved Ejection Fraction Heart Failure, and Left Ventricular Remodeling
por: Stencel, Jason, et al.
Publicado: (2023)

Biomarkers in heart failure with preserved ejection fraction
por: Meijers, W. C., et al.
Publicado: (2016)

Management of heart failure with preserved ejection fraction
por: Gard, Emma, et al.
Publicado: (2020)

Managing heart failure with preserved ejection fraction
por: Davidson, Alexander, et al.
Publicado: (2020)

Biomarkers in Heart Failure with Preserved Ejection Fraction
por: Bayes-Genis, Antoni, et al.
Publicado: (2022)

Comorbidities in heart failure with preserved ejection fraction
por: Deichl, Andrea, et al.
Publicado: (2022)

Left atrial ejection fraction and outcomes in heart failure with preserved ejection fraction
por: Kanagala, Prathap, et al.
Publicado: (2019)

Selective Homocysteine Lowering Gene Transfer Improves Infarct Healing, Attenuates Remodelling, and Enhances Diastolic Function after Myocardial Infarction in Mice
por: Muthuramu, Ilayaraja, et al.
Publicado: (2013)

Prognostic Value of Anxiety Between Heart Failure With Reduced Ejection Fraction and Heart Failure With Preserved Ejection Fraction
por: Lin, Tin‐Kwang, et al.
Publicado: (2019)

Impact of severe obesity on exercise performance in heart failure with preserved ejection fraction
por: Sarma, Satyam, et al.
Publicado: (2020)

Obesity-related heart failure with preserved ejection fraction: diagnostic and therapeutic challenges
por: Jung, Mi-Hyang, et al.
Publicado: (2023)

High-Density Lipoprotein-Targeted Therapies for Heart Failure
por: Mishra, Mudit, et al.
Publicado: (2020)

Right Heart Phenotype in Heart Failure With Preserved Ejection Fraction
por: Guazzi, Marco, et al.
Publicado: (2021)

Metabolomic Fingerprint of Heart Failure with Preserved Ejection Fraction
por: Zordoky, Beshay N., et al.
Publicado: (2015)

Animal models of heart failure with preserved ejection fraction
por: Conceição, G., et al.
Publicado: (2016)

Cell Therapy for Heart Failure With Preserved Ejection Fraction
por: Borlaug, Barry A., et al.
Publicado: (2016)

Hospitalisation in Patients With Heart Failure With Preserved Ejection Fraction
por: Nanayakkara, Shane, et al.
Publicado: (2018)

Modelling the complexity of heart failure with preserved ejection fraction
por: O’Gallagher, Kevin, et al.
Publicado: (2018)

Microvascular Rarefaction and Heart Failure With Preserved Ejection Fraction
por: Zeng, Heng, et al.
Publicado: (2019)

Heart Failure With Preserved Ejection Fraction: An Opportunity for Reflection
por: Gupta, Deepak K.
Publicado: (2017)

Strategies for management of heart failure with preserved ejection fraction
por: Winchester, David E.
Publicado: (2019)

Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
por: D’Amario, Domenico, et al.
Publicado: (2019)

Therapeutic Stalemate in Heart Failure With Preserved Ejection Fraction
por: Samson, Rohan, et al.
Publicado: (2021)

The Gut Microbiome of Heart Failure With Preserved Ejection Fraction
por: Beale, Anna L., et al.
Publicado: (2021)

Cell Therapy in Heart Failure with Preserved Ejection Fraction
por: Frljak, Sabina, et al.
Publicado: (2022)

Management strategies in heart failure with preserved ejection fraction
por: Wintrich, Jan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_okcsmuen3r86hbmo2cdp388abr