A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition

Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these include multiple physiological and biochemical differences among patients. A PBPK model of tacrolimus was developed, including a v...

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Detalles Bibliográficos
Autores principales: Emoto, Chie, Johnson, Trevor N., Hahn, David, Christians, Uwe, Alloway, Rita R., Vinks, Alexander A., Fukuda, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539708/
https://www.ncbi.nlm.nih.gov/pubmed/30843669
http://dx.doi.org/10.1002/psp4.12392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539708/
https://www.ncbi.nlm.nih.gov/pubmed/30843669
http://dx.doi.org/10.1002/psp4.12392

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