Physiologically‐Based Pharmacokinetic Models for CYP1A2 Drug–Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam

This study provides whole‐body physiologically‐based pharmacokinetic models of the strong index cytochrome P450 (CYP)1A2 inhibitor and moderate CYP3A4 inhibitor fluvoxamine and of the sensitive CYP1A2 substrate theophylline. Both models were built and thoroughly evaluated for their application in dr...

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Detalles Bibliográficos
Autores principales: Britz, Hannah, Hanke, Nina, Volz, Anke‐Katrin, Spigset, Olav, Schwab, Matthias, Eissing, Thomas, Wendl, Thomas, Frechen, Sebastian, Lehr, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539736/
https://www.ncbi.nlm.nih.gov/pubmed/30762305
http://dx.doi.org/10.1002/psp4.12397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539736/
https://www.ncbi.nlm.nih.gov/pubmed/30762305
http://dx.doi.org/10.1002/psp4.12397

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