Development of Oxygen-Bridged Pyrazole-Based Structures as Cannabinoid Receptor 1 Ligands

In this work, the synthesis of the cannabinoid receptor 1 neutral antagonists 8-chloro-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-4,5-dihydrobenzo-1H-6-oxa-cyclohepta[1,2-c]pyrazole-3-carboxamide 1a and its deaza N-cyclohexyl analogue 1b has led to a deepening of the structure-activity studies of this...

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Detalles Bibliográficos
Autores principales: Murineddu, Gabriele, Asproni, Battistina, Corona, Paola, Piras, Sandra, Lazzari, Paolo, Ruiu, Stefania, Legnani, Laura, Toma, Lucio, Pinna, Gérard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539809/
https://www.ncbi.nlm.nih.gov/pubmed/31035548
http://dx.doi.org/10.3390/molecules24091656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539809/
https://www.ncbi.nlm.nih.gov/pubmed/31035548
http://dx.doi.org/10.3390/molecules24091656

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