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Development of Oxygen-Bridged Pyrazole-Based Structures as Cannabinoid Receptor 1 Ligands
In this work, the synthesis of the cannabinoid receptor 1 neutral antagonists 8-chloro-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-4,5-dihydrobenzo-1H-6-oxa-cyclohepta[1,2-c]pyrazole-3-carboxamide 1a and its deaza N-cyclohexyl analogue 1b has led to a deepening of the structure-activity studies of this...
Autores principales: | Murineddu, Gabriele, Asproni, Battistina, Corona, Paola, Piras, Sandra, Lazzari, Paolo, Ruiu, Stefania, Legnani, Laura, Toma, Lucio, Pinna, Gérard A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539809/ https://www.ncbi.nlm.nih.gov/pubmed/31035548 http://dx.doi.org/10.3390/molecules24091656 |
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