Dihydropyrazole Derivatives Containing Benzo Oxygen Heterocycle and Sulfonamide Moieties Selectively and Potently Inhibit COX-2: Design, Synthesis, and Anti-Colon Cancer Activity Evaluation

Cyclooxygenase-2 (COX-2) as a rate-limiting metabolism enzyme of arachidonic acid has been found to be implicated in tumor occurrence, angiogenesis, metastasis as well as apoptosis inhibition, regarded as an attractive therapeutic target for cancer therapy. In our research, a series of dihydropyrazo...

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Detalles Bibliográficos
Autores principales: Yan, Xiao-Qiang, Wang, Zhong-Chang, Zhang, Bo, Qi, Peng-Fei, Li, Gui-Gen, Zhu, Hai-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539903/
https://www.ncbi.nlm.nih.gov/pubmed/31052167
http://dx.doi.org/10.3390/molecules24091685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539903/
https://www.ncbi.nlm.nih.gov/pubmed/31052167
http://dx.doi.org/10.3390/molecules24091685

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