Effects of Silymarin on the In Vivo Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats

Herein, the effect of silymarin pretreatment on the pharmacokinetics of simvastatin in rats was evaluated. To ensure the accuracy of the results, a rapid and sensitive UPLC–MS/MS method was established for simultaneous quantification of simvastatin (SV) and its active metabolite simvastatin acid (SV...

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Detalles Bibliográficos
Autores principales: Li, Ying, Wu, Yin, Li, Ya-Jing, Meng, Lu, Ding, Cong-Yang, Dong, Zhan-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540003/
https://www.ncbi.nlm.nih.gov/pubmed/31035343
http://dx.doi.org/10.3390/molecules24091666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540003/
https://www.ncbi.nlm.nih.gov/pubmed/31035343
http://dx.doi.org/10.3390/molecules24091666

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