Cargando…

Effects of Silymarin on the In Vivo Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats

Herein, the effect of silymarin pretreatment on the pharmacokinetics of simvastatin in rats was evaluated. To ensure the accuracy of the results, a rapid and sensitive UPLC–MS/MS method was established for simultaneous quantification of simvastatin (SV) and its active metabolite simvastatin acid (SV...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Ying, Wu, Yin, Li, Ya-Jing, Meng, Lu, Ding, Cong-Yang, Dong, Zhan-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540003/ https://www.ncbi.nlm.nih.gov/pubmed/31035343 http://dx.doi.org/10.3390/molecules24091666

Ejemplares similares

A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents
por: Ogungbenro, Kayode, et al.
Publicado: (2019)

An Accurate and Effective Method for Measuring Osimertinib by UPLC-TOF-MS and Its Pharmacokinetic Study in Rats
por: Dong, Song-Tao, et al.
Publicado: (2018)

Baicalein inhibits the pharmacokinetics of simvastatin in rats via regulating the activity of CYP3A4
por: Meng, Meng, et al.
Publicado: (2021)

Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats
por: Feng, Xinchi, et al.
Publicado: (2021)

Simultaneous measurement of tadehaginoside and its principal metabolite in rats by HPLC–MS/MS and its application in pharmacokinetics and tissue distribution study
por: Zhang, Cai-Yun, et al.
Publicado: (2021)

Genomewide Association Study of Simvastatin Pharmacokinetics
por: Mykkänen, Anssi J. H., et al.
Publicado: (2022)

The Effect of Apigenin on Pharmacokinetics of Imatinib and Its Metabolite N-Desmethyl Imatinib in Rats
por: Liu, Xian-yun, et al.
Publicado: (2013)

Toxicology and Pharmacokinetics Study of Intradiscal Injection of Simvastatin in Rabbits
por: Huang, Xiaodong, et al.
Publicado: (2021)

The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers
por: Sornsuvit, Chuleegone, et al.
Publicado: (2018)

Effect of Cilostazol on the Pharmacokinetics of Simvastatin in Healthy Subjects
por: Kim, Jung-Ryul, et al.
Publicado: (2019)

Detection and characterization of simvastatin and its metabolites in rat tissues and biological fluids using MALDI high resolution mass spectrometry approach
por: Yin, Wencui, et al.
Publicado: (2022)

Plasma Pharmacokinetic Determination of Canagliflozin and Its Metabolites in a Type 2 Diabetic Rat Model by UPLC-MS/MS
por: Dong, Song-tao, et al.
Publicado: (2018)

In vitro Dissolution Testing and Pharmacokinetic Studies of Silymarin Solid Dispersion After Oral Administration to Healthy Pigs
por: Xu, Ying, et al.
Publicado: (2022)

Effects of Simvastatin on the Metabolism of Vonoprazan in Rats Both in vitro and in vivo
por: Hong, Yun, et al.
Publicado: (2022)

Synthesis, Characterization and Quantification of Simvastatin Metabolites and Impurities
por: Bhatia, Manish S., et al.
Publicado: (2011)

Antiviral Activities of Silymarin and Derivatives
por: Liu, Ching-Hsuan, et al.
Publicado: (2019)

A Sample and Sensitive HPLC-MS/MS Method for Simultaneous Determination of Ziyuglycoside I and Its Metabolite Ziyuglycoside II in Rat Pharmacokinetics
por: Li, Zhi-Feng, et al.
Publicado: (2018)

Pharmacokinetics of Tyrosol Metabolites in Rats
por: Lee, Da-Hye, et al.
Publicado: (2016)

Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo
por: Wang, Ying, et al.
Publicado: (2020)

The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats
por: Lin, Dan, et al.
Publicado: (2012)

Skin Protective Activity of Silymarin and its Flavonolignans
por: Vostálová, Jitka, et al.
Publicado: (2019)

Pharmacokinetics and Main Metabolites of Anwulignan in Mice
por: Chen, Cong, et al.
Publicado: (2022)

A Simple HPLC Method for the Quantitative Determination of Silybin in Rat Plasma: Application to a Comparative Pharmacokinetic Study on Commercial Silymarin Products
por: Ha, Eun-Sol, et al.
Publicado: (2019)

Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD
por: Xie, Ying, et al.
Publicado: (2017)

Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
por: Kaddurah-Daouk, Rima, et al.
Publicado: (2011)

Protective effect of silymarin on doxorubicin-induced cardiotoxicity in rats
por: Stilinović, Nebojša, et al.
Publicado: (2012)

Ameliorative Effect of Silymarin on Scopolamine-induced Dementia in Rats
por: El-Marasy, Salma A., et al.
Publicado: (2018)

Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats
por: Wang, Lan, et al.
Publicado: (2018)

Parent-Metabolite Pharmacokinetic Modeling of Formononetin and Its Active Metabolites in Rats after Oral Administration of Formononetin Formulations
por: Kim, Ju Hee, et al.
Publicado: (2022)

Metabolites profiling and pharmacokinetics of troxipide and its pharmacodynamics in rats with gastric ulcer
por: Guo, Hongbin, et al.
Publicado: (2020)

Impact of Vancomycin‐Induced Changes in the Intestinal Microbiota on the Pharmacokinetics of Simvastatin
por: Sunwoo, Jung, et al.
Publicado: (2020)

Simvastatin Loaded Dissolvable Microneedle Patches with Improved Pharmacokinetic Performance
por: , Zulcaif, et al.
Publicado: (2022)

Effects of Simvastatin on Pharmacokinetics and Anticoagulant Effects of Dabigatran in Healthy Subjects
por: Chung, Hyewon, et al.
Publicado: (2023)

Effects of Ginkgo leaf tablets on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism
por: Dong, Baiping, et al.
Publicado: (2018)

Silymarin and diabetic nephropathy
por: Rafieian-Kopaie, Mahmoud, et al.
Publicado: (2012)

Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants
por: Wang, Le-le, et al.
Publicado: (2022)

Population Pharmacokinetics of Phosphocreatine and Its Metabolite Creatine in Children With Myocarditis
por: He, Huan, et al.
Publicado: (2020)

Correction: Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
por: Kaddurah-Daouk, Rima, et al.
Publicado: (2013)

Metabolite Signature of Simvastatin Treatment Involves Multiple Metabolic Pathways
por: Fernandes Silva, Lilian, et al.
Publicado: (2022)

Silymarin Induces Insulin Resistance through an Increase of Phosphatase and Tensin Homolog in Wistar Rats
por: Cheng, Kai-Chun, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_oekcf88o6vkjd38v27uj83shf8