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Plasticity and Constraints of tRNA Aminoacylation Define Directed Evolution of Aminoacyl-tRNA Synthetases

Genetic incorporation of noncanonical amino acids (ncAAs) has become a powerful tool to enhance existing functions or introduce new ones into proteins through expanded chemistry. This technology relies on the process of nonsense suppression, which is made possible by directing aminoacyl-tRNA synthet...

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Detalles Bibliográficos
Autores principales: Crnković, Ana, Vargas-Rodriguez, Oscar, Söll, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540133/
https://www.ncbi.nlm.nih.gov/pubmed/31075874
http://dx.doi.org/10.3390/ijms20092294