Generation of an MC3R knock-out pig by CRSPR/Cas9 combined with somatic cell nuclear transfer (SCNT) technology

BACKGROUND: Melanocortin 3 receptor (MC3R), a rhodopsin-like G protein-coupled receptor, is an important regulator of metabolism. Although MC3R knock-out (KO) mice and rats were generated in earlier studies, the function of MC3R remains elusive. Since pig models have many advantages over rodents in...

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Detalles Bibliográficos
Autores principales: Yin, Yajun, Hao, Haiyang, Xu, Xingbin, Shen, Liangcai, Wu, Wenjing, Zhang, Jin, Li, Qiuyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540458/
https://www.ncbi.nlm.nih.gov/pubmed/31138220
http://dx.doi.org/10.1186/s12944-019-1073-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540458/
https://www.ncbi.nlm.nih.gov/pubmed/31138220
http://dx.doi.org/10.1186/s12944-019-1073-9

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