Naturally Occurring Sesquiterpene Lactone-Santonin, Exerts Anticancer Effects in Multi-Drug Resistant Breast Cancer Cells by Inducing Mitochondrial Mediated Apoptosis, Caspase Activation, Cell Cycle Arrest, and by Targeting Ras/Raf/MEK/ERK Signaling Pathway

BACKGROUND: Sesquiterpene lactones have gained tremendous attention owing to their potent anticancer properties. The main focus of this study was to evaluate the anticancer effects of a naturally occurring sesquiterpene lactone, santonin, against human breast cancer SK-BR-3 cells. MATERIAL/METHODS:...

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Detalles Bibliográficos
Autores principales: Wu, Zhiqiang, Wang, Chenchen, Huang, Mingzhu, Tao, Zhonghua, Yan, Wangjun, Du, Yiqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Lab/In Vitro Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540632/
https://www.ncbi.nlm.nih.gov/pubmed/31101800
http://dx.doi.org/10.12659/MSM.915246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540632/
https://www.ncbi.nlm.nih.gov/pubmed/31101800
http://dx.doi.org/10.12659/MSM.915246

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