The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates

The concept of targeted drug conjugates has been successfully translated to clinical practice in oncology. Whereas the majority of cytotoxic effectors in drug conjugates are directed against either DNA or tubulin, our study aimed to validate nuclear export inhibition as a novel effector principle in...

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Detalles Bibliográficos
Autores principales: Klahn, Philipp, Fetz, Verena, Ritter, Antje, Collisi, Wera, Hinkelmann, Bettina, Arnold, Tatjana, Tegge, Werner, Rox, Katharina, Hüttel, Stephan, Mohr, Kathrin I., Wink, Joachim, Stadler, Marc, Wissing, Josef, Jänsch, Lothar, Brönstrup, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540907/
https://www.ncbi.nlm.nih.gov/pubmed/31191875
http://dx.doi.org/10.1039/c8sc05542d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540907/
https://www.ncbi.nlm.nih.gov/pubmed/31191875
http://dx.doi.org/10.1039/c8sc05542d

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