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The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates
The concept of targeted drug conjugates has been successfully translated to clinical practice in oncology. Whereas the majority of cytotoxic effectors in drug conjugates are directed against either DNA or tubulin, our study aimed to validate nuclear export inhibition as a novel effector principle in...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540907/ https://www.ncbi.nlm.nih.gov/pubmed/31191875 http://dx.doi.org/10.1039/c8sc05542d |