Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions

T cells in chronic viral infections are featured by premature aging with accelerated telomere erosion, but the mechanisms underlying telomere attrition remain unclear. Here, we employed human CD4 T cells treated with KML001 (a telomere-targeting drug) as a model to investigate the role of telomere i...

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Detalles Bibliográficos
Autores principales: Cao, Dechao, Zhao, Juan, Nguyan, Lam N., Nguyen, Lam N. T., Khanal, Sushant, Dang, Xindi, Schank, Madison, Chand Thakuri, Bal K., Wu, Xiao Y., Morrison, Zheng D., El Gazzar, Mohamed, Zou, Yue, Ning, Shunbin, Wang, Ling, Moorman, Jonathan P., Yao, Zhi Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540964/
https://www.ncbi.nlm.nih.gov/pubmed/31191531
http://dx.doi.org/10.3389/fimmu.2019.01152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540964/
https://www.ncbi.nlm.nih.gov/pubmed/31191531
http://dx.doi.org/10.3389/fimmu.2019.01152

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