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Empirical ways to identify novel Bedaquiline resistance mutations in AtpE
Clinical resistance against Bedaquiline, the first new anti-tuberculosis compound with a novel mechanism of action in over 40 years, has already been detected in Mycobacterium tuberculosis. As a new drug, however, there is currently insufficient clinical data to facilitate reliable and timely identi...
Autores principales: | Karmakar, Malancha, Rodrigues, Carlos H. M., Holt, Kathryn E., Dunstan, Sarah J., Denholm, Justin, Ascher, David B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541270/ https://www.ncbi.nlm.nih.gov/pubmed/31141524 http://dx.doi.org/10.1371/journal.pone.0217169 |
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