Site-specific PEGylation of micro-plasmin for improved thrombolytic therapy through engineering enhanced resistance against serpin mediated inhibition

The relatively rapid inhibition of microplasmin by α(2)-AP leads to short functional half-life of the molecule in vivo, causing inefficient clot dissolution, even after site-specific, local catheter-based delivery. Here, we describe a PEGylation approach for improving the therapeutic potential via i...

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Detalles Bibliográficos
Autores principales: Kaur, Navneet, Sinha, Prakash Kumar, Sahni, Girish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541275/
https://www.ncbi.nlm.nih.gov/pubmed/31141522
http://dx.doi.org/10.1371/journal.pone.0217234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541275/
https://www.ncbi.nlm.nih.gov/pubmed/31141522
http://dx.doi.org/10.1371/journal.pone.0217234

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