Restoration of susceptibility to amikacin by 8-hydroxyquinoline analogs complexed to zinc

Gram-negative pathogens resistant to amikacin and other aminoglycosides of clinical relevance usually harbor the 6’-N-acetyltransferase type Ib [AAC(6')-Ib], an enzyme that catalyzes inactivation of the antibiotic by acetylation using acetyl-CoA as donor substrate. Inhibition of the acetylating...

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Detalles Bibliográficos
Autores principales: Magallon, Jesus, Chiem, Kevin, Tran, Tung, Ramirez, Maria S., Jimenez, Veronica, Tolmasky, Marcelo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541283/
https://www.ncbi.nlm.nih.gov/pubmed/31141575
http://dx.doi.org/10.1371/journal.pone.0217602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541283/
https://www.ncbi.nlm.nih.gov/pubmed/31141575
http://dx.doi.org/10.1371/journal.pone.0217602

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