Heck- and Suzuki-coupling approaches to novel hydroquinone inhibitors of calcium ATPase

In this study, we explored Heck- and Suzuki-coupling methodology to modify the template 2,5-di-tert-butylhydroquinone (BHQ, 2), an inhibitor of the enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA). We found that by utilizing Suzuki coupling, we could successfully attach a six-carbon tether...

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Detalles Bibliográficos
Autores principales: Kempton, Robert J, Kidd-Kautz, Taylor A, Laurenceau, Soizic, Paula, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541364/
https://www.ncbi.nlm.nih.gov/pubmed/31164934
http://dx.doi.org/10.3762/bjoc.15.94

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541364/
https://www.ncbi.nlm.nih.gov/pubmed/31164934
http://dx.doi.org/10.3762/bjoc.15.94

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