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Heck- and Suzuki-coupling approaches to novel hydroquinone inhibitors of calcium ATPase
In this study, we explored Heck- and Suzuki-coupling methodology to modify the template 2,5-di-tert-butylhydroquinone (BHQ, 2), an inhibitor of the enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA). We found that by utilizing Suzuki coupling, we could successfully attach a six-carbon tether...
Autores principales: | Kempton, Robert J, Kidd-Kautz, Taylor A, Laurenceau, Soizic, Paula, Stefan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541364/ https://www.ncbi.nlm.nih.gov/pubmed/31164934 http://dx.doi.org/10.3762/bjoc.15.94 |
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