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Single-Dose CRISPR/Cas9 Therapy Extends Lifespan of Mice with Hutchinson-Gilford Progeria Syndrome

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated aging. The major underlying genetic cause is a substitution mutation in the gene coding for lamin A, causing the production of a toxic isoform called progerin. Here we s...

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Detalles Bibliográficos
Autores principales: Beyret, Ergin, Liao, Hsin-Kai, Yamamoto, Mako, Hernandez-Benitez, Reyna, Fu, Yunpeng, Erikson, Galina, Reddy, Pradeep, Belmonte, Juan Carlos Izpisua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541418/
https://www.ncbi.nlm.nih.gov/pubmed/30778240
http://dx.doi.org/10.1038/s41591-019-0343-4