Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

We have used misfolded prion protein (PrP*) as a model to investigate how mammalian cells recognize and degrade misfolded GPI-anchored proteins. While most misfolded membrane proteins are degraded by proteasomes, misfolded GPI-anchored proteins are primarily degraded in lysosomes. Quantitative flow...

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Detalles Bibliográficos
Autores principales: Zavodszky, Eszter, Hegde, Ramanujan S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541436/
https://www.ncbi.nlm.nih.gov/pubmed/31094677
http://dx.doi.org/10.7554/eLife.46740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541436/
https://www.ncbi.nlm.nih.gov/pubmed/31094677
http://dx.doi.org/10.7554/eLife.46740

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