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Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2

Imprinted X-inactivation silences genes exclusively on the paternally-inherited X-chromosome and is a paradigm of transgenerational epigenetic inheritance in mammals. Here, we test the role of maternal vs. zygotic Polycomb repressive complex 2 (PRC2) protein EED in orchestrating imprinted X-inactiva...

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Detalles Bibliográficos
Autores principales:	Harris, Clair, Cloutier, Marissa, Trotter, Megan, Hinten, Michael, Gayen, Srimonta, Du, Zhenhai, Xie, Wei, Kalantry, Sundeep
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541438/ https://www.ncbi.nlm.nih.gov/pubmed/30938678 http://dx.doi.org/10.7554/eLife.44258

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