Critical role for Piccolo in synaptic vesicle retrieval

Loss of function of the active zone protein Piccolo has recently been linked to a disease, Pontocerebellar Hypoplasia type 3, which causes brain atrophy. Here, we address how Piccolo inactivation in rat neurons adversely affects synaptic function and thus may contribute to neuronal loss. Our analysi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ackermann, Frauke, Schink, Kay Oliver, Bruns, Christine, Izsvák, Zsuzsanna, Hamra, F Kent, Rosenmund, Christian, Garner, Craig Curtis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541439/
https://www.ncbi.nlm.nih.gov/pubmed/31074746
http://dx.doi.org/10.7554/eLife.46629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541439/
https://www.ncbi.nlm.nih.gov/pubmed/31074746
http://dx.doi.org/10.7554/eLife.46629

Ejemplares similares