Generation of new hair cells by DNA methyltransferase (Dnmt) inhibitor 5-azacytidine in a chemically-deafened mouse model

Regeneration of mature mammalian inner ear hair cells remains to be a challenge. This study aims to evaluate the ability of DNA methyltransferase (Dnmt) inhibitor 5-azacytidine (5-aza) to generate outer hair cells (OHCs) in a chemically-deafened adult mouse model. 5-aza was administrated into the mo...

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Detalles Bibliográficos
Autores principales: Deng, Xin, Liu, Zhenjie, Li, Xiaoyang, Zhou, Yang, Hu, Zhengqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541592/
https://www.ncbi.nlm.nih.gov/pubmed/31142766
http://dx.doi.org/10.1038/s41598-019-44313-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541592/
https://www.ncbi.nlm.nih.gov/pubmed/31142766
http://dx.doi.org/10.1038/s41598-019-44313-0

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