HIV Infection Induces Extracellular Cathepsin B Uptake and Damage to Neurons

HIV-associated neurocognitive disorders prevail in 20–50 percent of infected individuals. Macrophages transmigrate through the blood brain barrier during HIV-1 infection, triggering neuronal dysfunction. HIV-infected macrophages secrete cathepsin B (CATB), and serum amyloid p component (SAPC), induc...

Descripción completa

Detalles Bibliográficos
Autores principales: Cantres-Rosario, Yisel M., Ortiz-Rodríguez, Sarah C., Santos-Figueroa, Aemil G., Plaud, Marines, Negron, Karla, Cotto, Bianca, Langford, Dianne, Melendez, Loyda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541605/
https://www.ncbi.nlm.nih.gov/pubmed/31142756
http://dx.doi.org/10.1038/s41598-019-44463-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541605/
https://www.ncbi.nlm.nih.gov/pubmed/31142756
http://dx.doi.org/10.1038/s41598-019-44463-1

Ejemplares similares