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HIV Infection Induces Extracellular Cathepsin B Uptake and Damage to Neurons

HIV-associated neurocognitive disorders prevail in 20–50 percent of infected individuals. Macrophages transmigrate through the blood brain barrier during HIV-1 infection, triggering neuronal dysfunction. HIV-infected macrophages secrete cathepsin B (CATB), and serum amyloid p component (SAPC), induc...

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Detalles Bibliográficos
Autores principales:	Cantres-Rosario, Yisel M., Ortiz-Rodríguez, Sarah C., Santos-Figueroa, Aemil G., Plaud, Marines, Negron, Karla, Cotto, Bianca, Langford, Dianne, Melendez, Loyda M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541605/ https://www.ncbi.nlm.nih.gov/pubmed/31142756 http://dx.doi.org/10.1038/s41598-019-44463-1

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