Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis

Vacuole membrane protein (VMP1) is a putative autophagy protein, which together with Beclin-1 acts as a molecular switch in activating autophagy. In the present study the role of VMP1 was analysed in CD34(+) cells of cord blood (CB) and primary acute myeloid leukemia (AML) cells and cell lines. An i...

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Detalles Bibliográficos
Autores principales: Folkerts, Hendrik, Wierenga, Albertus T., van den Heuvel, Fiona A., Woldhuis, Roy R., Kluit, Darlyne S., Jaques, Jennifer, Schuringa, Jan Jacob, Vellenga, Edo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541608/
https://www.ncbi.nlm.nih.gov/pubmed/31142733
http://dx.doi.org/10.1038/s41419-019-1648-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541608/
https://www.ncbi.nlm.nih.gov/pubmed/31142733
http://dx.doi.org/10.1038/s41419-019-1648-4

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