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Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis

Vacuole membrane protein (VMP1) is a putative autophagy protein, which together with Beclin-1 acts as a molecular switch in activating autophagy. In the present study the role of VMP1 was analysed in CD34(+) cells of cord blood (CB) and primary acute myeloid leukemia (AML) cells and cell lines. An i...

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Detalles Bibliográficos
Autores principales:	Folkerts, Hendrik, Wierenga, Albertus T., van den Heuvel, Fiona A., Woldhuis, Roy R., Kluit, Darlyne S., Jaques, Jennifer, Schuringa, Jan Jacob, Vellenga, Edo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541608/ https://www.ncbi.nlm.nih.gov/pubmed/31142733 http://dx.doi.org/10.1038/s41419-019-1648-4

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