Curcumin Inhibits the PERK-eIF2α-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model

Oxidative stress plays a crucial role in the occurrence and development of osteoarthritis (OA) through the activation of endoplasmic reticulum (ER) stress. Curcumin is a polyphenolic compound with significant antioxidant and anti-inflammatory activity among various diseases. To elucidate the role of...

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Detalles Bibliográficos
Autores principales: Feng, Kai, Ge, Yuwei, Chen, Zhaoxun, Li, Xiaodong, Liu, Zhiqing, Li, Xunlin, Li, Hui, Tang, Tingting, Yang, Fei, Wang, Xiaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541984/
https://www.ncbi.nlm.nih.gov/pubmed/31223428
http://dx.doi.org/10.1155/2019/8574386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541984/
https://www.ncbi.nlm.nih.gov/pubmed/31223428
http://dx.doi.org/10.1155/2019/8574386

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