Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome

Understanding why a transcription factor (TF) binds to a specific DNA element in the genome and whether that binding event affects transcriptional output remains a great challenge. In this study, we demonstrate that TF binding in the genome follows inversion symmetry (IS). In addition, the specific...

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Detalles Bibliográficos
Autores principales: Coons, Laurel A., Burkholder, Adam B., Hewitt, Sylvia C., McDonnell, Donald P., Korach, Kenneth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542189/
https://www.ncbi.nlm.nih.gov/pubmed/31152742
http://dx.doi.org/10.1016/j.isci.2019.04.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542189/
https://www.ncbi.nlm.nih.gov/pubmed/31152742
http://dx.doi.org/10.1016/j.isci.2019.04.006

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