Klotho Protein Reduced the Expression of Matrix Metalloproteinase-1 (MMP-1) and Matrix Metalloproteinase-3 (MMP-3) in Fibroblasts from Patients with Pelvic Organ Prolapse (POP) by Down-Regulating the Phosphorylation of ERK1/2

BACKGROUND: Pelvic organ prolapse (POP) is due to age-related atrophy and the weakening of the tissues of the pelvic floor, with degradation of collagen and extracellular matrix (ECM) by metalloproteinases (MMPs). This study aimed to investigates the role of the age-related enzyme klotho, encoded by...

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Detalles Bibliográficos
Autores principales: Qiu, Jun, Qin, Menglu, Fan, Bozhen, Chen, Xinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542300/
https://www.ncbi.nlm.nih.gov/pubmed/31116709
http://dx.doi.org/10.12659/MSM.913623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542300/
https://www.ncbi.nlm.nih.gov/pubmed/31116709
http://dx.doi.org/10.12659/MSM.913623

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