A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection

Chagas disease, caused by the parasite Trypanosoma cruzi, develops into chronic Chagas’ cardiomyopathy in ~30% of infected individuals, characterized by conduction disorders, arrhythmias, heart failure, and even sudden cardiac death. Current anti-parasitic treatments are plagued by significant side...

Descripción completa

Detalles Bibliográficos
Autores principales: Barry, Meagan A., Versteeg, Leroy, Wang, Qian, Pollet, Jeroen, Zhan, Bin, Gusovsky, Fabian, Bottazzi, Maria Elena, Hotez, Peter J., Jones, Kathryn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542517/
https://www.ncbi.nlm.nih.gov/pubmed/31145733
http://dx.doi.org/10.1371/journal.pntd.0007413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542517/
https://www.ncbi.nlm.nih.gov/pubmed/31145733
http://dx.doi.org/10.1371/journal.pntd.0007413

Ejemplares similares