Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases

There is a need to develop asymmetric routes to functionalised β-lactams, which remain the most important group of antibacterials. Here we describe biocatalytic and protein engineering studies concerning carbapenem biosynthesis enzymes, aiming to enable stereoselective production of functionalised c...

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Detalles Bibliográficos
Autores principales: Hamed, Refaat B., Gomez-Castellanos, J. Ruben, Henry, Luc, Warhaut, Sven, Claridge, Timothy D. W., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542682/
https://www.ncbi.nlm.nih.gov/pubmed/31157308
http://dx.doi.org/10.1038/s42004-018-0106-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542682/
https://www.ncbi.nlm.nih.gov/pubmed/31157308
http://dx.doi.org/10.1038/s42004-018-0106-z

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