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Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases
There is a need to develop asymmetric routes to functionalised β-lactams, which remain the most important group of antibacterials. Here we describe biocatalytic and protein engineering studies concerning carbapenem biosynthesis enzymes, aiming to enable stereoselective production of functionalised c...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542682/ https://www.ncbi.nlm.nih.gov/pubmed/31157308 http://dx.doi.org/10.1038/s42004-018-0106-z |