Combinatorial mutation on the β-glycosidase specific to 7-β-xylosyltaxanes and increasing the mutated enzyme production by engineering the recombinant yeast

Taxol is a “blockbuster” antitumor drug produced by Taxus species with extremely low amount, while its analogue 7-β-xylosyl-10-deacetyltaxol is generally much higher in the plants. Both the fungal enzymes LXYL-P1−1 and LXYL-P1−2 can convert 7-β-xylosyl-10-deacetyltaxol into 10-deacetyltaxol for Taxo...

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Detalles Bibliográficos
Autores principales: Chen, Jing-Jing, Liang, Xiao, Wang, Fen, Wen, Yan-Hua, Chen, Tian-Jiao, Liu, Wan-Cang, Gong, Ting, Yang, Jin-Ling, Zhu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542770/
https://www.ncbi.nlm.nih.gov/pubmed/31193781
http://dx.doi.org/10.1016/j.apsb.2018.11.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542770/
https://www.ncbi.nlm.nih.gov/pubmed/31193781
http://dx.doi.org/10.1016/j.apsb.2018.11.003

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