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Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting

Multidrug resistance (MDR) has been considered as a huge challenge to the effective chemotherapy. Therefore, it is necessary to develop new strategies to effectively overcome MDR. Here, based on the previous research of N-(2-hydroxypropyl)methacrylamide (HPMA) polymer–drug conjugates, we designed an...

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Detalles Bibliográficos
Autores principales: Zhou, Minglu, Li, Lijia, Li, Lian, Lin, Xi, Wang, Fengling, Li, Qiuyi, Huang, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542785/
https://www.ncbi.nlm.nih.gov/pubmed/31193791
http://dx.doi.org/10.1016/j.apsb.2018.11.005