PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery. Optimization has focused on selection of target genes and exact localization around the ribosome binding site, but surprisingly a length optimum around...

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Detalles Bibliográficos
Autores principales: Goltermann, Lise, Yavari, Niloofar, Zhang, Meiqin, Ghosal, Anubrata, Nielsen, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542938/
https://www.ncbi.nlm.nih.gov/pubmed/31178830
http://dx.doi.org/10.3389/fmicb.2019.01032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542938/
https://www.ncbi.nlm.nih.gov/pubmed/31178830
http://dx.doi.org/10.3389/fmicb.2019.01032

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