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Accelerated Current Decay Kinetics of a Rare Human Acid-Sensing ion Channel 1a Variant That Is Used in Many Studies as Wild Type

Acid-sensing ion channels (ASICs) are neuronal Na(+)-permeable ion channels that are activated by extracellular acidification and are involved in fear sensing, learning, neurodegeneration after ischemia, and in pain sensation. We have recently found that the human ASIC1a (hASIC1a) wild type (WT) clo...

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Detalles Bibliográficos
Autores principales: Vaithia, Anand, Vullo, Sabrina, Peng, Zhong, Alijevic, Omar, Kellenberger, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542941/
https://www.ncbi.nlm.nih.gov/pubmed/31178694
http://dx.doi.org/10.3389/fnmol.2019.00133