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Evaluating the effects of design parameters on the performances of phase I trial designs
Numerous designs have been proposed for phase I clinical trials. Although studies have compared their performances, few have considered the effects of changing design parameters. In this article, we review a few popular designs, including the 3 + 3, continuous reassessment method (CRM), Bayesian opt...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543020/ https://www.ncbi.nlm.nih.gov/pubmed/31193764 http://dx.doi.org/10.1016/j.conctc.2019.100379 |