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Evaluating the effects of design parameters on the performances of phase I trial designs

Numerous designs have been proposed for phase I clinical trials. Although studies have compared their performances, few have considered the effects of changing design parameters. In this article, we review a few popular designs, including the 3 + 3, continuous reassessment method (CRM), Bayesian opt...

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Detalles Bibliográficos
Autores principales: Zhu, Yaqian, Hwang, Wei-Ting, Li, Yimei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543020/
https://www.ncbi.nlm.nih.gov/pubmed/31193764
http://dx.doi.org/10.1016/j.conctc.2019.100379

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