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Investigation of factors influencing the separation of diastereomers of phosphorothioated oligonucleotides
This study presents a systematic investigation of factors influencing the chromatographic separation of diastereomers of phosphorothioated pentameric oligonucleotides as model solutes. Separation was carried out under ion-pairing conditions using an XBridge C(18) column. For oligonucleotides with a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543027/ https://www.ncbi.nlm.nih.gov/pubmed/31020370 http://dx.doi.org/10.1007/s00216-019-01813-2 |