Enaminone Modulators of Extrasynaptic α(4)β(3)δ γ-Aminobutyric Acid(A) Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning

Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABA(A)Rs) that rapidly internalize during status epilepticus (SE). Extrasynaptic GABA(A)Rs, such as those containing α(4...

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Detalles Bibliográficos
Autores principales: Johnstone, Timothy B. C., McCarren, Hilary S., Spampanato, Jay, Dudek, F. Edward, McDonough, John H., Hogenkamp, Derk, Gee, Kelvin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543275/
https://www.ncbi.nlm.nih.gov/pubmed/31178732
http://dx.doi.org/10.3389/fphar.2019.00560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543275/
https://www.ncbi.nlm.nih.gov/pubmed/31178732
http://dx.doi.org/10.3389/fphar.2019.00560

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