Cargando…

Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease

Interferon regulatory factors (IRFs) are a family of homologous proteins that regulate the transcription of interferons (IFNs) and IFN-induced gene expression. As such they are important modulating proteins in the Toll-like receptor (TLR) and IFN signaling pathways, which are vital elements of the i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Antonczyk, Aleksandra, Krist, Bart, Sajek, Malgorzata, Michalska, Agata, Piaszyk-Borychowska, Anna, Plens-Galaska, Martyna, Wesoly, Joanna, Bluyssen, Hans A. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543449/ https://www.ncbi.nlm.nih.gov/pubmed/31178872 http://dx.doi.org/10.3389/fimmu.2019.01176

Ejemplares similares

Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease
por: Szelag, Malgorzata, et al.
Publicado: (2016)

SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications
por: Plens-Gałąska, Martyna, et al.
Publicado: (2022)

Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription
por: Piaszyk-Borychowska, Anna, et al.
Publicado: (2019)

Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs
por: Plens-Galaska, Martyna, et al.
Publicado: (2018)

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses
por: Michalska, Agata, et al.
Publicado: (2018)

Time-dependent recruitment of GAF, ISGF3 and IRF1 complexes shapes IFNα and IFNγ-activated transcriptional responses and explains mechanistic and functional overlap
por: Sekrecka, Agata, et al.
Publicado: (2023)

STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1
por: Blaszczyk, Katarzyna, et al.
Publicado: (2015)

Editorial: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets
por: Lee, Chien-Kuo, et al.
Publicado: (2019)

Dysregulated Interferon Response and Immune Hyperactivation in Severe COVID-19: Targeting STATs as a Novel Therapeutic Strategy
por: Eskandarian Boroujeni, Mahdi, et al.
Publicado: (2022)

Identification of STAT1 and STAT3 Specific Inhibitors Using Comparative Virtual Screening and Docking Validation
por: Szelag, Malgorzata, et al.
Publicado: (2015)

The epigenetic landscape of clear-cell renal cell carcinoma
por: Kluzek, Katarzyna, et al.
Publicado: (2015)

Data Mining of Atherosclerotic Plaque Transcriptomes Predicts STAT1-Dependent Inflammatory Signal Integration in Vascular Disease
por: Sikorski, Krzysztof, et al.
Publicado: (2014)

Potential Approaches and Recent Advances in Biomarker Discovery in Clear-Cell Renal Cell Carcinoma
por: Majer, Weronika, et al.
Publicado: (2015)

Thyroid cancers of follicular origin in a genomic light: in-depth overview of common and unique molecular marker candidates
por: Pstrąg, Natalia, et al.
Publicado: (2018)

ESR Method in Monitoring of Nanoparticle Endocytosis in Cancer Cells
por: Krzyminiewski, Ryszard, et al.
Publicado: (2020)

FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data
por: Zodro, Elżbieta, et al.
Publicado: (2013)

STAT1 as a central mediator of IFNγ and TLR4 signal integration in vascular dysfunction
por: Sikorski, Krzysztof, et al.
Publicado: (2012)

Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection
por: Irving, Aaron T., et al.
Publicado: (2020)

STAT2-directed pathogen responses
por: Bluyssen, Hans
Publicado: (2015)

Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors
por: Wrzesiński, Tomasz, et al.
Publicado: (2015)

A type I IFN–Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors
por: Chen, Yi-Ling, et al.
Publicado: (2013)

Identification of RCC Subtype-Specific microRNAs–Meta-Analysis of High-Throughput RCC Tumor microRNA Expression Data
por: Kajdasz, Arkadiusz, et al.
Publicado: (2021)

Phosphorylation of interferon regulatory factor 9 (IRF9)
por: Paul, Alvin, et al.
Publicado: (2023)

RNAlign2D: a rapid method for combined RNA structure and sequence-based alignment using a pseudo-amino acid substitution matrix
por: Woźniak, Tomasz, et al.
Publicado: (2021)

Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development
por: Yamamoto, Michio, et al.
Publicado: (2011)

Interferon Regulatory Factor (Irf)-1 and Irf-2 Regulate Interferon γ–Dependent Cyclooxygenase 2 Expression
por: Blanco, Jorge C. G., et al.
Publicado: (2000)

IRF4 as an Oncogenic Master Transcription Factor
por: Wong, Regina Wan Ju, et al.
Publicado: (2022)

Transcriptional reprogramming by mutated IRF4 in lymphoma
por: Schleussner, Nikolai, et al.
Publicado: (2023)

Transcription factor IRF8 directs a silencing programme for T(H)17 cell differentiation
por: Ouyang, Xinshou, et al.
Publicado: (2011)

IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs
por: Saeki, Keita, et al.
Publicado: (2023)

Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
por: Campos Carrascosa, Lucia, et al.
Publicado: (2017)

Regulatory effects of IRF4 on immune cells in the tumor microenvironment
por: Lu, Jing, et al.
Publicado: (2023)

Specific enhancer selection by IRF3, IRF5 and IRF9 is determined by ISRE half-sites, 5′ and 3′ flanking bases, collaborating transcription factors and the chromatin environment in a combinatorial fashion
por: Csumita, Mária, et al.
Publicado: (2020)

An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells
por: Davies, James, et al.
Publicado: (2021)

Deficiency in the Transcription Factor Interferon Regulatory Factor (Irf)-2 Leads to Severely Compromised Development of Natural Killer and T Helper Type 1 Cells
por: Lohoff, Michael, et al.
Publicado: (2000)

Reduction of greenhouse gases emission through the use of tiletamine and zolazepam
por: Lachowska, Sonia, et al.
Publicado: (2022)

OR26-5 Musashi-2 Regulatory Interactions Promote Adrenal Steroidogenesis
por: Baldwin, Amber, et al.
Publicado: (2022)

Regulation of Lymphocyte Apoptosis by Interferon Regulatory Factor 4 (IRF-4)
por: Fanzo, Jessica C., et al.
Publicado: (2003)

Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation
por: Platanitis, Ekaterini, et al.
Publicado: (2018)

STAT1-Dependent Signal Integration between IFNγ and TLR4 in Vascular Cells Reflect Pro-Atherogenic Responses in Human Atherosclerosis
por: Chmielewski, Stefan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ubqgc0jp61o7kkqqtrbbm7f0aq