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Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia

Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely understood. We profiled microglia of a discrete developing CNS...

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Detalles Bibliográficos
Autores principales: Anderson, Sarah R., Roberts, Jacqueline M., Zhang, Jianmin, Steele, Michael R., Romero, Cesar O., Bosco, Alejandra, Vetter, Monica L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544177/
https://www.ncbi.nlm.nih.gov/pubmed/31091440
http://dx.doi.org/10.1016/j.celrep.2019.04.062