Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors

Lynx1 is the first three-finger prototoxin found in the mammalian central nervous system. It is a GPI-anchored protein modulating nicotinic acetylcholine receptors (nAChRs) in the brain. Besides the brain, the Lynx1 protein was found in the lung and kidney. Endogenous Lynx1 controls the nicotine-ind...

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Detalles Bibliográficos
Autores principales: Bychkov, Maxim, Shenkarev, Zakhar, Shulepko, Mikhail, Shlepova, Olga, Kirpichnikov, Mikhail, Lyukmanova, Ekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544245/
https://www.ncbi.nlm.nih.gov/pubmed/31150435
http://dx.doi.org/10.1371/journal.pone.0217339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544245/
https://www.ncbi.nlm.nih.gov/pubmed/31150435
http://dx.doi.org/10.1371/journal.pone.0217339

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