Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma

We aimed to explore whether the combination of intradermal DNA vaccination, to boost immune response against melanoma antigens, and immune checkpoint blockade, to alleviate immunosuppression, improves antitumor effectiveness in a murine B16F10 melanoma tumor model. Compared to single treatments, a c...

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Detalles Bibliográficos
Autores principales: Kos, Spela, Lopes, Alessandra, Preat, Veronique, Cemazar, Maja, Lampreht Tratar, Ursa, Ucakar, Bernard, Vanvarenberg, Kevin, Sersa, Gregor, Vandermeulen, Gaelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544376/
https://www.ncbi.nlm.nih.gov/pubmed/31150505
http://dx.doi.org/10.1371/journal.pone.0217762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544376/
https://www.ncbi.nlm.nih.gov/pubmed/31150505
http://dx.doi.org/10.1371/journal.pone.0217762

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