PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice

Mechanisms driving the initiation of brain folding are incompletely understood. We have previously characterized mouse models recapitulating human PIK3CA-related brain overgrowth, epilepsy, dysplastic gyrification and hydrocephalus (Roy et al., 2015). Using the same, highly regulatable brain-specifi...

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Detalles Bibliográficos
Autores principales: Roy, Achira, Murphy, Rory M, Deng, Mei, MacDonald, James W, Bammler, Theo K, Aldinger, Kimberly A, Glass, Ian A, Millen, Kathleen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544437/
https://www.ncbi.nlm.nih.gov/pubmed/31094678
http://dx.doi.org/10.7554/eLife.45961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544437/
https://www.ncbi.nlm.nih.gov/pubmed/31094678
http://dx.doi.org/10.7554/eLife.45961

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