Dual Chemical Probes Enable Quantitative System-Wide Analysis of Protein Prenylation and Prenylation Dynamics

Post-translational farnesylation or geranylgeranylation at a C-terminal cysteine residue regulates localization and function of over 100 proteins, including the Ras isoforms, and is a therapeutic target in diseases including cancer and infection. Here we report global and selective profiling of pren...

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Detalles Bibliográficos
Autores principales: Storck, Elisabeth M., Morales-Sanfrutos, Julia, Serwa, Remigiusz A., Panyain, Nattawadee, Lanyon-Hogg, Thomas, Tolmachova, Tanya, Ventimiglia, Leandro N., Martin-Serrano, Juan, Seabra, Miguel C., Wojciak-Stothard, Beata, Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544531/
https://www.ncbi.nlm.nih.gov/pubmed/30936521
http://dx.doi.org/10.1038/s41557-019-0237-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544531/
https://www.ncbi.nlm.nih.gov/pubmed/30936521
http://dx.doi.org/10.1038/s41557-019-0237-6

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