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Dual Chemical Probes Enable Quantitative System-Wide Analysis of Protein Prenylation and Prenylation Dynamics
Post-translational farnesylation or geranylgeranylation at a C-terminal cysteine residue regulates localization and function of over 100 proteins, including the Ras isoforms, and is a therapeutic target in diseases including cancer and infection. Here we report global and selective profiling of pren...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544531/ https://www.ncbi.nlm.nih.gov/pubmed/30936521 http://dx.doi.org/10.1038/s41557-019-0237-6 |