CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity

RhoGTPases regulate cytoskeletal dynamics, migration and cell-cell adhesion in endothelial cells. Besides regulation at the level of guanine nucleotide binding, they also undergo post-translational modifications, for example ubiquitination. RhoGTPases are ubiquitinated by Cullin RING ligases which a...

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Detalles Bibliográficos
Autores principales: Majolée, Jisca, Pronk, Manon C. A., Jim, Kin K., van Bezu, Jan S. M., van der Sar, Astrid M., Hordijk, Peter L., Kovačević, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544660/
https://www.ncbi.nlm.nih.gov/pubmed/31148579
http://dx.doi.org/10.1038/s41598-019-44595-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544660/
https://www.ncbi.nlm.nih.gov/pubmed/31148579
http://dx.doi.org/10.1038/s41598-019-44595-4

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